Test Results Equal Shitty News

There’s alot happening all of a sudden – I’m going to break it up into a few posts:

Monday my husband and I sat down with Dr. Hail Mary thinking we were there to ask some last minute questions and then charge into IVF4: The Final Frontier. I had repeated the endometrial receptivity/Beta 3 integrin biopsy on March 31 and those results were already in.

Good news: the Beta 3 integrin was now positive. Bad news: my lining was still out of phase “despite aggressive treatment.” Dr. Hail Mary explained that this meant the cells weren’t getting the message from the progesterone and estrogen and therefore the lining was not receptive to implantation.

Think of it this way: my lining is Quantity over Quality.

Basically: there’s enough lining but implantation is highly improbable in that environment.

He said, “In this business we pay so much attention to egg quality that sometimes we disregard the environment we’ll be putting that embryo into.”

He figures this is the most likely reason I miscarried and have had 3 unsuccessful IUIs and 3 failed IVFs.

Y’all: my eco-system is off.

He doesn’t know why my lining is out of phase. He said it shouldn’t be an age issue and there’s every likelihood that it’s always been this way – meaning I may have had trouble whenever we’d tried to conceive. He’s not sure of that by the way, but it’s a possibility.

Oh and our fertility insurance runs out May 31 (it’s attached to my husband’s contract which ends May 31) so basically we have 8 weeks of coverage left.

It’s always somethin’ am I right?

The doctor recommends more testing cycles to see if he can figure out a) what may be causing the out-of-phase lining and more importantly b) if he can fix it. There’s some trial-and-error involved here since he doesn’t know why his usual methods didn’t fix things.

Given our waining insurance situation he suggested we proceed with our final IVF cycle (insurance covers 4), go through stims, see if there’s anyone to freeze, freeze them, THEN do at least one (if not more) cycle of testing to try to make my lining receptive and then hopefully move forward with a FET (Frozen Embryo Transfer) or perhaps use a gestational carrier (insert the giggles of two midwestern lower middle class people in their 40s with no retirement plan).

Basically we’re looking at a rough estimate of 4ish months (2 months for IVF, 1ish months for testing, 1 cycle for FET) before I can do that transfer….so end of July or August.

He was….not hopeful….pretty matter of fact….and honest in his confusion over why my body doesn’t seem to be playing ball. My husband asked if there’s the possibility that he might not be able to fix this phase issue to which the doctor said, “that is a real possibility.”

It’s not just my age anymore, there’s actual stuff keeping me from getting pregnant.

This pill is far more bitter and harder to swallow than I’d anticipated.

It feels like my already low chances of getting pregnant at 43 just dropped. Alot.

The doctor estimated that a woman with my ovarian reserve has approximately a 10% chance of GETTING pregnant. STAYING pregnant is another matter…..that number is significantly lower.

We’ve been talking alot and mulling over what to do….and I think we know what’s ahead of us.

More on that tomorrow.

 

Test Cycle: Results Starting to Roll In

So I’m at the end of the test cycle and we’re starting to learn stuff. Lots of stuff is looking good and thus far there are 3 things that have indicated that I’ll need some tweaking to the protocol:

My protein-C levels are slightly elevated, as are my antiphospholipid antibodies (say that 3 times fast: antiphospholid, antiphopholidaliheid, antiphosphiliphosenfeffer……) thankfully also called APA. This means I have an increased risk of clotting and the elevated levels may cause difficulty with implantation, and could also possibly be a cause of miscarriage. I’ll take a blood thinner to help with this, likely Lovenox. So….yay, one more injection! (I realize that they are just words on a page but I want you to feel the sarcasm…the deep deep chasm of sarcasm).

Also, I have a methylenetetrahydrofolate reductase (MTHFR) deficiency. When the body is MTHFR deficient its ability to absorb folate (also known as vitamin B9), such as folic acid, is inhibited. Folic acid and B9 are both essential to the development and health of the fetus. So, treatment of this involves taking supplemental folic acid or folate and perhaps another vitamin (I didn’t get all that as I was standing in the middle of a grocery store taking notes on the phone – I think I did a fairly decent job otherwise).

It’ll still be another week or so until the last of the blood tests and the biopsy results are in, but so far no deal breakers, all manageable stuff. I did ask the nurse if the above elevated levels and deficiencies could have been part of why I’ve had three embryo transfers and no pregnancies and she said yes. It’s not a definitive answer as to why things haven’t worked yet but it’s at least information…..and information is good.

And, now we know we can do some easy stuff to try to have a different outcome.

Unrelated: I really want to see Non-Stop, the new Liam Neeson movie that comes out this weekend. That man can throw a throat punch and I like to live vicariously through that sort of thing.